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Explains what antipsychotics are used for, how the medication works, possible side effects and information about withdrawal.

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View this information as a PDF new window. Every antipsychotic has its own possible side effects. Not everyone who takes antipsychotics will experience side effects, but many people do. This lists the most serious side effects that are possible with any antipsychotic drug.

Some of these side effects are rare. This list has links to find out more information about each drug, including information about side effects. See our on coping with side effects for guidance on what to do if you experience one of these side effects.

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Antimuscarinic effects are side effects caused by changes to the level of the chemical acetylcholine in your body. These effects are sometimes called anticholinergic effects. If your level of acetylcholine changes, this can have effects all over your body. These effects include:. Antimuscarinic effects are more common with some antipsychotics than others. In particular, clozapine may be more likely to cause severe constipation than other types of antipsychotic. These effects can also happen with other types of medication, such as tricyclic antidepressants and anti-Parkinson's drugs. Quietiapine made me feel stoned initially, with huge weight gain.

Bed-wetting can be a side effect of antipsychotics. It is more common with some antipsychotics than others. Agranulocytosis is a blood disorder which involves the loss of one type of white blood cell. It means that you are more likely to catch infections and less able to fight them. It is very serious and people have been known to die from it.

If you have the following symptoms, it may be a that your immune system is not working as well as it should:. The risk of agranulocytosis is higher with clozapine than with other antipsychotics. If you take clozapine, you will have your blood tested regularly to check for this.

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These include deep vein thrombosis DVT and pulmonary thrombosis blood clot in the lungwhich can be life-threatening. Antipsychotics can cause problems with regulating your body temperature. It may become too high or too low, both of which can make you feel unwell. All antipsychotics also have the potential to cause narrow-angle glaucoma. This is a medical emergency. If you've ever had glaucoma or eye problems, you should be very cautious about taking antipsychotic drugs.

You may want to avoid certain antipsychotics completely, especially those with antimuscarinic effects. See our s on taking antipsychotics safely and dosage of antipsychotics for more information on the risks of heart problems with antipsychotics. This includes information on how you can manage these risks. Taking antipsychotics can increase your risk of developing metabolic syndrome.

If you experiencing metabolic syndrome, this means you are at higher risk of developing:. This risk of this is increased even more if you have an unhealthy lifestyle. Your doctors may suggest trying to eat a healthier diet and get enough physical activity can help to reduce this risk. See our s on food and mood for healthy eating tips, and physical activity and your mental health for lots of ways to get more active. If you have a difficult relationship with food and eating, our s on eating problems may help.

You will also need to have regular health checks before and during your treatment.

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See our on taking antipsychotics safely for more information. It can happen as a side effect of taking antipsychotics. It may also occur as a withdrawal symptom if you stop taking antipsychotics. If it does occur, it usually develops rapidly over 24 to 72 hours. High temperature and rigidity are usually the first symptoms to appear. This means NMS can sometimes be confused with an infection. In rare cases, it can be fatal. If you experience NMS, the treatment is most likely to involve admitting you to hospital, stopping your antipsychotic medication and reducing your fever.

Some other methods of treatment are used, although the evidence for the use of these is not as strong. These methods may include using:. The symptoms may last for days, or even weeks, after coming off the antipsychotic that's causing them. Many people who have had NMS once go on to get it again. If you experience NMS, you should only take antipsychotics afterwards if they are essential for your mental health. And you should have the lowest dosage possible that still gives the positive effects.

Antipsychotics interfere with the brain chemical dopamine, which is important in controlling movement. Antipsychotics may therefore cause movement disorders. These are most common with first generation older antipsychotics and less likely with the newer antipsychotics. They include the following:. These effects are known as Parkinsonism, and they include the following:. Akathisia is a feeling of restlessness that can affect your body and your emotions.

For example, you might:. Doctors might confuse these symptoms and think you are anxious or agitated. If they don't know that you have akathisia, they may suggest taking a higher dose of your antipsychotics, to help you feel calmer. So if you are diagnosed with akathisia, your doctor or psychiatrist may suggest taking another medication to reduce its effects, as well as your antipsychotic. Muscle spasms are when a muscle in your body contracts against your control, and you cannot relax the muscle.

They can be painful and may have serious effects. For example:. Sedation, or sleepiness, is a common side effect of many antipsychotics. It is more common with certain antipsychotics than others, such as chlorpromazine and olanzapine. Sedation can happen during the day as well as at night. So if you experience this you might find it very hard to get up in the morning.

Or it might feel difficult to motivate yourself to be active during the day. Many antipsychotics have the potential to cause fits. If you've ever had fits in the past, you should be particularly cautious about taking antipsychotic drugs. Sexual problems are a possible side effect of certain antipsychotics. The symptoms vary for different people, and may include:. If you have a penis, you may experience spontaneous ejaculation or priapism a painful erection that lasts for several hours. If you experience priapism, it requires urgent medical attention.

If you have a vagina, you may experience vaginal dryness. And if you would normally have periods, they might stop or become irregular. But these changes can be unpredictable. Your periods may return, so you could still get pregnant if you have unprotected sex. Some second generation antipsychotics may be less likely to cause these sexual side effects. You can speak to your doctor, psychiatrist or pharmacist if you are concerned about these effects. After having blood tests, it turns out that my prolactin levels have sky-rocketed, which is why I experienced those side effects.

I am also now at risk of osteoporosis in the future. Some people experience suicidal thoughts and behaviours while taking antipsychotics. This can happen particularly in the early stages of taking this medication. If you are concerned about experiencing suicidal feelings while taking antipsychotics, speak to your doctor or psychiatrist.

Get emergency advice. Tardive dyskinesia TD is a side effect of certain medications, mainly antipsychotics. It involves experiencing sudden, jerky or slow twisting movements in your face or body. See our s on tardive dyskinesia to find out more. This includes information on what TD is, what treatments and support are available, and ways to help yourself cope. Tardive psychosis is a term used to describe new psychotic symptoms that begin after you have been taking antipsychotics for a while.

Some scientists believe that these symptoms may be caused by your medication, not your original illness returning. The word 'tardive' means that it's a delayed effect of the medication. This is especially important if you have been taking it for a long time, as withdrawing slowly gives your brain time to readjust. Weight gain is a very common side effect of many antipsychotics, particularly some of the second generation newer drugs.

This may be because antipsychotics increase your appetite, so you want to eat more than usual. They may also cause you to become less active, for example if they make you feel very tired. If you put on a lot of weight, this can increase your risk of developing diabetes and other physical health problems. It's also understandable if you feel upset or frustrated about these changes to your body.

If you experience weight gain, your doctor or psychiatrist may suggest switching to another antipsychotic medication. They may also suggest that you try to eat a healthy diet and increase your level of physical activity.

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